PRODID:-//hacksw/handcal//NONSGML v1.0//EN BEGIN:VEVENT UID:66171633900939 DTSTAMP: 20211012t1500000z LOCATION://www.androidjugaad.com/webinar/growing-concern-off-target-effects-measure-minimize-off-target-effects-genome-editing-experiments描述:位置:\n//www.androidjugaad.com/webinar/growing-concern-off-target-effects-measure-minimize-off-target-effects-genome-editing-experiments\n\nSpeaker:\nPandhita Pochanard\n\ n摘要:\nDate: 2021年10月12日\n\nTime:nCRISPR-Cas9是一种以核酸酶为基础的基因组编辑系统,在从基础研究到治疗学的广泛应用中,其应用呈指数级增长。nCRISPR介导的基因组编辑是一种非常强大的工具,能够在广泛的不同细胞类型和基因座中实现高编辑效率。然而,这种高编辑效率是有代价的:脱靶乳沟。这些对基因组的非预期的“偏离目标”编辑可能会导致不希望的表型,并减缓项目的进展。在本报告中,我们将讨论基因组编辑过程中脱靶效应的一些常见原因,并探讨一些策略,以帮助减少iPSCs和t细胞中CRISPR编辑过程中脱靶事件的发生。\n\n\n学习目标\n *在CRISPR-Cas9编辑中描述脱靶事件的影响\n *讨论检测和识别脱靶事件的方法\n *讨论在高保真Cas9变体中帮助最小化脱靶事件的策略和优化gRNA设计\n\n\n \n\n *网络研讨会将提供无限的按需观看after live event. \n\n \n\nLabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety. URL;VALUE=URI://www.androidjugaad.com/webinar/growing-concern-off-target-effects-measure-minimize-off-target-effects-genome-editing-experiments SUMMARY:The growing concern of off-target effects: How to measure and minimize off-target effects in your genome editing experiments. DTSTART:20211012T150000Z DTEND:20211012T160000Z END:VEVENT END:VCALENDAR
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